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UFC Fight Night 251: Cannonier vs. Rodrigues was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on February 15, 2025, at the UFC Apex in Enterprise, Nevada, part of the Las Vegas Valley, United States. A middleweight bout between former UFC Middleweight Championship challenger Jared Cannonier and former LFA Middleweight Champion Gregory Rodrigues headlined the event.